ALB and lung carcinoma: More sophisticated, trimeric fusion proteins have been achieved consisting of blood plasma protein HSA that was decorated with a PAMAM corona (HSA-PAMAM) to enable efficient uptake into mammalian cells such as A549 lung cancer and HeLa.20,198,200 As cargo, different protein enzymes such as C3 toxin, β-galactosidase and the enzymatic subunit of the Clostridium botulinum C2 toxin, C2I were assembled with HSA-PAMAM by an avidin (Av) linker.