We measured the OCR in pancreatic cancer cells with Nupr1 siRNA-mediated knockdown (Fig. 2B) or knockout by CRISPR-Cas9 (Fig. 2C), as well as in pancreatic acini obtained from Nupr1-KO and WT mice (Fig. 2D). This evidence concerns the gene NUPR1 and familial pancreatic carcinoma.