In marked contrast to Pyrin-deficient mice, selective deletion of executioner caspases 3 and 7 in IECs caused Casp3/7IEC-KO mice to lose significantly more body weight during initial stages of infection relative to littermate Casp3/7F/F mice that do express these executioner caspases in IECs (Fig. 5e). The gene discussed is MEFV; the disease is infection.