Furthermore, we purified vtRNAs and U1 spliceosomal small nuclear RNA, a 2,2,7 trimethylguanosine capped RNA and thus not a DUSP11 substrate, from latent and lytic BC-3 cells using antisense oligonucleotide selection and transfected the purified RNA into HCT116 ISG54-luciferase reporter cells (Fig. 5h). This evidence concerns the gene DUSP11 and breast cancer.