SiglecF-CD11b+F4/80+ cells of the stromal vascular fraction (SVF) of the white adipose tissue (WAT) were collected from mice with genetically (ob/ob) or environmentally induced (15-week, HF diet-fed) obesity (Supplementary Fig. 1b). This evidence concerns the gene ITGAM and obesity due to melanocortin 4 receptor deficiency.