IRS2 and hydrops fetalis: Since it has been shown that the M1- and M2-type MΦ fractions are clearly separable using CD11c and CD206, the classic markers of M1- and M2-type MΦs, respectively23, we investigated the expression levels of Irs2 in siglecF-CD11b+F4/80+CD11c+ cells (M1-type MΦs) and siglecF-CD11b+F4/80+CD206+ cells (M2-type MΦs) in the SVCs of the adipose tissue derived from NC and HF diet-fed mice.