Although the Irs2 expression levels in the siglecF-CD11b+F4/80+ cells of the MIrs2KO mice were markedly reduced, the expression levels of IR, IL-4R and STAT6 did not differ between the control and MIrs2KO mice under the HF diet condition (Supplementary Fig. 4a). This evidence concerns the gene ITGAM and hydrops fetalis.