In fact, mice overexpressing CA-FoxO1 in the myeloid cells, which is thought to be associated with maintained Irs2 expression and decreased IL-4 signaling due to stabilization of FoxO1/HDAC3/NCoR1 corepressor complex in the MΦs, showed reduced M2a-subtype MΦ activation and increased inflammation and insulin resistance under the HF diet condition35. This evidence concerns the gene IRS2 and Insulin resistance.