Moreover, the IL-4-induced Irs2 and Akt phosphorylation were significantly enhanced in the peritoneal MΦs of HF diet-fed MIRKO mice, along with increased MΦ Irs2 expression, although IL-4-induced STAT6 phosphorylation did not differ between control and MIRKO mice (Fig. 5b and Supplementary Fig. 7a). Here, IRS2 is linked to hydrops fetalis.