In fact, the blood glucose levels during the pyruvate tolerance test (PTT) and expression levels of phosphoenolpyruvate carboxykinase (PEPCK) and glucose 6-phosphatase (G6Pase) in the liver were significantly increased in the HF diet-fed MIrs2KO mice (Supplementary Fig. 3c, d). The gene discussed is G6PC1; the disease is hydrops fetalis.