Till now RACK1 expression in the carcinogenic process of human colonic epithelium has not been investigated, therefore we detected RACK1 expression during the human colon epithelial carcinogenesis including 63 normal colonic mucosa (NCM), 60 colonic inflammatory polyps, 60 colonic adenomas, 180 colon adenocarcinomas, and 40 lymph node metastases (LNM) by immunohistochemical staining. This evidence concerns the gene RACK1 and colon adenoma.