To determine whether RACK1-induced autophagy promotes colon cancer cell proliferation and inhibits colon cancer cell apoptosis, we used siRNA against ATG5 or BECN1 to inhibit autophagy in the RACK1 OE colon cancer cells (Fig. 6a), and analyzed the changes of cells proliferation and apoptosis. This evidence concerns the gene BECN1 and malignant colon neoplasm.