RACK1 and cancer: As SW480 and SW620 cell lines were derived from the primary cancer and lymph node metastasis of the same patient respectively, and RACK1 expression was markedly higher in SW620 cells relative to SW480 cells, we established SW480 colon cancer cell lines with stable RACK1 overexpression (SW480-RACK1 OE), and SW620 colon cancer cell lines with stable RACK1 knockdown (SW620-RACK1 KD) (Fig. 2a).