In summary, we speculate that TBX2 plays a crucial role within the NB CRC, in a cooperative MYCN/TBX2 regulated p53-p21-DREAM-CDE/CHR pathway controlling G2/M cell cycle genes.Together with data from previous reports, we propose that TBX2 repression of p21 enforces MYCN controlled p21 repression56 which is followed by activation of CDK2/cyclin A, p107/p130 phosphorylation and finally DREAM complex repression. This evidence concerns the gene RBL1 and neuroblastoma.