In keeping with this finding, TBX2 repressed genes in both CLB-GA and IMR-5/75 NB cells were found to be enriched for TP53 targets while common activated genes were enriched for FOXM1 targets, more specifically p53–p21–DREAM–E2F/CHR pathway known to control G2/M transition55. This evidence concerns the gene CDKN1A and neuroblastoma.