To test the possibility to drug the transcriptional addiction of NB cells to the highly expressed TBX2 gene and CRC genes, we combined the CDK7 inhibitor THZ1, which was previously shown to affect transcription of lineage-dependency genes in NB39, with the bromo-domain inhibitor JQ1, which causes transcriptional repression of SE associated oncogenes40. This evidence concerns the gene TBX2 and neuroblastoma.