As these data collectively suggest a role for TBX2 in control of a FOXM1/E2F-driven gene regulatory network driving proliferation, we explored the phenotypical effects of TBX2 KD in NB cells following prolonged lentiviral short hairpin RNA mediated KD of TBX2 in IMR-32, CLB-GA and SK-N-AS NB cell lines with high TBX2 expression. The gene discussed is TBX2; the disease is neuroblastoma.