We specifically looked for rare TBX2 encompassing amplicons in a series of 556 high-risk NB cases29 and detected a single MYCN-amplified case with an additional 1.076 Mb focal 17q23.2 amplification (Fig. 2e and Supplementary Fig. 2e) encompassing only six protein-coding genes including the transcription factors TBX2 and TBX4. Of further note, a previously reported focal high level 1.8 Mb gain of a chromosome 17q23 segment in the NB cell line MP-N-TS also encompasses the TBX2 locus30,31. The gene discussed is TBX4; the disease is neuroblastoma.