Using a similar approach as for MYCN amplified IMR-5/75 cells, we also investigated the TBX2 transcriptional regulated network in the non-MYCN amplified CLB-GA NB cells and observed similar downstream targets and enriched genes sets as those observed in IMR-5/75 upon TBX2 KD (Supplementary Fig. 4a–d, Supplementary Data 3 and 5), with the E2F/FOXM1 axis being most prominent. Here, TBX2 is linked to neuroblastoma.