H19 and colorectal carcinoma: Furthermore, univariate (Fig. 1c) and multivariate Cox regression analyses (hazard ratio (HR) = 2.383, 95% confidence interval (CI) = 1.157–4.909, P = 0.018, Fig. 1d) further identified that H19 was an independent prognosis factor for CRC aggressiveness with significant hazard ratios for predicting clinical outcome.