Mitochondrial dysfunctions that lead to the activation of the apoptotic cascade are one of the key pathophysiological mechanisms associated with neuropathic diseases.7 Mitochondrial membrane permeabilization releases cytochrome C, which subsequently forms a complex that initiates the cleavage and activation of caspases.8, 9, 10 The spinal nerve ligation (SNL) peripheral neuropathy model activates a neuronal apoptotic cascade that includes the release of cytochrome C into the cytosol and caspase‐3 activation.11 The gene discussed is CYCS; the disease is peripheral neuropathy.