TLR4 and mucopolysaccharidosis: A causative factor in MPS neuroinflammation is likely the accumulation of HS in the CNS, likely through its interactions with TLRs and other immune regulators; many of which have been revealed to comprise HS‐binding motifs, such as TLR4, TLR2, Interleukin 1 Receptor Associated Kinase 1 (IRAK1) and the inflammasome receptor NLRP3 (Simon Davis and Parish 2013).