Also, the monogenic form of type 2 diabetes due to mutations in the KATP Kir6.2 subunit as well as gene polymorphism resulting in the in-excitable β-cells, thereby affecting insulin secretion, cause the increase of “empty” β-cells lacking the mature β-cell markers and instead expressing multipotency markers reflecting dedifferentiation. The gene discussed is INS; the disease is type 2 diabetes mellitus.