Among them, nine proteins, including ANXA4,25 EPS8L2,26 HCCR1,27 HLA‐DPB1,28 HLA‐DRA1,29 HPRT1,30 LMP2,31 S100A432 and TOX,33 have been reported to be involved in cancer progression as shown in Figure 3A. Growing evidence indicates that elevated S100A4 protein levels are associated with the progression and angiogenesis of several malignant tumors, including breast cancer,17 non‐small cell lung cancer,18 prostate cancer,19 and colon cancer.34 Therefore, we hypothesized that OSX might exert its effects on cell migration and angiogenesis by regulating S100A4 expression in breast cancer. This evidence concerns the gene EPS8L2 and cancer.