Although a recent study indicated that OSX could alter the expression profile of several metastasis‐associated genes, such as those encoding vascular endothelial growth factor (VEGF), matric metalloproteinase 9 (MMP‐9), β‐catenin, and E‐cadherin in human breast cancer cells,7 whether the expression of OSX is critical for cancer metastasis is unknown, and the underlying mechanism remains to be defined. This evidence concerns the gene SP7 and breast cancer.