An increase in S100A4 protein expression has been correlated with a worse prognosis for patients with different types of cancer including breast, colon, gastric, lung, hepatocellular, and pancreatic cancer,34, 36, 37, 38, 39 which suggested that OSX could be used as a target gene to improve cancer prognosis. Here, S100A4 is linked to pancreatic neoplasm.