As shown in Figure 1A, the expression levels of OSX in the more invasive breast cancer cell lines such as T‐47D, MDA‐MB‐231 and MDA‐MB‐468 were much higher than those in the weakly metastatic breast cancer cell line MCF7 and the non‐cancerous breast epithelium cells MCF 10A, suggesting that OSX expression levels correlate positively with the invasion ability of these cell lines. This evidence concerns the gene SP7 and breast cancer.