SP7 and cancer: Although a recent study indicated that OSX could alter the expression profile of several metastasis‐associated genes, such as those encoding vascular endothelial growth factor (VEGF), matric metalloproteinase 9 (MMP‐9), β‐catenin, and E‐cadherin in human breast cancer cells,7 whether the expression of OSX is critical for cancer metastasis is unknown, and the underlying mechanism remains to be defined.