Nuclear factor (NF)‐κB, as a key transcriptional factor, controls inflammatory response in obesity‐related cardiomyopathy.27 As Figure 5D and E showed, PF‐8380 decreased HFD‐induced IκB phosphorylation and degradation (P < 0.01), as compared with vehicle‐treated obese mice. Here, NFKB1 is linked to obesity due to melanocortin 4 receptor deficiency.