Cardiac inflammation is a key characteristic of obesity‐related cardiomyopathy, including increasing secretion of inflammatory cytokines and transcriptional activities.26 As Figure 4A and C showed, obese mouse had remarkable induction of inflammatory factors, including TNF‐α, IL‐6 and iNOS (P < 0.01), but administration of PF‐8380 effectively decreased these upregulation in obese mice (P < 0.05). Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.