For example, Adiponectin, an adipose‐secreted adipokine, mediates the modulation of hypertrophic signals in the heart.34 Leptin, another adipocyte‐derived 16‐kD peptide, induces hypertrophy in neonatal rat ventricular myocytes.35 In our study, specific autotaxin inhibitor effectively improved HFD‐induced cardiac hypertrophy, dysfunction and inflammation in mice. Here, ENPP2 is linked to cardiac hypertrophy.