ENPP2 and metabolic disease: Adipose tissues are major source of circulating autotaxin and other inflammatory cytokines in obese status.22 Adipose‐specific deletion of autotaxin causes approximately 40% reduction in circulating LPA, suggests that adipocyte is the major source of circulating autotaxin in mice.22 Adipocyte‐specific deletion of autotaxin protects against HFD‐induced metabolic disorders in mouse model.33 Similarly, there are already amounts of studies that support the links between heart and peripheral tissues.