Including cancer cells, fibroblasts, endothelial cells, immune inflammatory cells, adipocytes, extracellular matrix molecules and soluble factors, a tumour mass contain various cellular demands and dynamic energetics.75 A recent perspective from Ying Zhang et al has highlighted the metabolic challenges faced by tumour antigen‐specific CD8+ tumour‐infiltrating lymphocytes (TILs) in TME which ultimately results in “functional exhaustion” of TILs. The gene discussed is CD8A; the disease is neoplasm.