NRIP1 and obesity due to melanocortin 4 receptor deficiency: Study concluded that IRE1α is responsible for driving obesity and abnormal metabolic deregulations primarily by curbing WAT browning.5 Another important observation is put forward by Pu‐Ste Liu et al suggesting the activation of receptor interacting protein 140 (RIP140), present on macrophages, through high‐fat diet (HFD).