TP53 and cancer: It is now believed that internal metabolism of cancer cells not only helps support the malignant growth but also affects malignant cells phenotype.85 The residency of different malignant phenotypes in the presence of dissimilar immune cells within TME is a well reported evidence.86 Loss of p‐53 tumour suppressor to contribute in malignant transformation87; mutation‐driven metabolic reprogramming through oncometabolites88; glucose deprivation89 and lactate accumulation90 in cancer cells are few of the examples of metabolism induced malignant transformation.