HIF1A and atherosclerosis: Activation of monocytes in response to oxLDL, LPS and hypoxia (all present in atherosclerosis) generates pro‐inflammatory signals inciting NF‐κβ which modulates HIF‐1α that raises the GLUT‐1 expression to increase the uptake of glucose within macrophages (Figure 1).44, 45 As discussed earlier, pro‐inflammatory M1 choose glycolysis as preferential energy getting path.