The Hippo signalling core kinases MST1/2 and downstream LATS1/2 phosphorylate YAP/TAZ, and promote their cytoplasmic sequestration and degradation.13, 14 Inhibition of MST1/2 and LATS1/2 by DLG5 silencing promotes the nuclear localization of YAP.10 Furthermore, TAZ, a YAP paralogue, is crucial for BCSCs.15, 16 Accordingly, we have been suggested that DLG5 may regulate TAM sensitivity by changing TAZ expression and nuclear translocation to modulate the stemness of breast cancer cells. The gene discussed is MST1; the disease is breast cancer.