In fact, ROC curve analyses confirmed that the presence of MetS, a greater number of MetS criteria, or circulating CRP levels might be used as additional diagnostic factors for Sig‐PCa when are added to the common risk factors mentioned above (ie age, family history, PSA, 5α reductase inhibitors intake, DRE, prostate volume and number of biopsies) with an AUC of 0.78 (0.72‐0.84), 0.78 (0.73‐0.84) and 0.77 (0.72‐0.83) respectively (Figure 2A). Here, CRP is linked to posterior cortical atrophy.