Therefore, based on these associations, and to accurately determine whether the presence of MetS, a greater number of MetS criteria, or circulating CRP levels might be used as predictive factors of Sig‐PCa independently, we adjusted these three variables by age, family history, PSA, 5α reductase inhibitors intake, DRE, prostate volume and number of biopsies (Table 5). This evidence concerns the gene CRP and posterior cortical atrophy.