Overexpression of TSG101 in cancers is found to activate multiple important pathways, including PI3K/Akt and MAPK/ERK pathways.21 In addition, TSG101 is reported to play a role in promoting HCC cell growth,22 however, the underlined mechanism and the potential role of TSG101 in human HCC migration and invasion remains unknown, which should be fully clarified. The gene discussed is TSG101; the disease is cancer.