Among the changed proteins, PEG10 has been demonstrated to promote cancer cell proliferation, migration and invasion in various human cancers,24, 25, 26, 27 and it has been reported to be involved in the regulation of the cell cycle related regulatory factors and the extracellular matrix metalloproteinases.27, 28, 33, 34 Thus, we has been suggested that whether PEG10 was involved in TSG101 regulated HCC cell proliferation, migration and invasion. The gene discussed is TSG101; the disease is hepatocellular carcinoma.