AKT1 and hepatocellular carcinoma: Overexpression of TSG101 in cancers is found to activate multiple important pathways, including PI3K/Akt and MAPK/ERK pathways.21 In addition, TSG101 is reported to play a role in promoting HCC cell growth,22 however, the underlined mechanism and the potential role of TSG101 in human HCC migration and invasion remains unknown, which should be fully clarified.