In this study, we firstly got 18 differentially expressed circulating microRNAs in plasma from ACS patients by using high‐throughput sequencing and then identified the function of miR‐185‐5p as a key regulator of angiogenesis by targeting cathepsin K (CatK), which plays an important role in regulating vascular repair.14 In vivo studies demonstrated that endogenous reduction of miR‐185‐5p was vital to the recovery of heart function after ischaemia in mice with MI. This evidence concerns the gene CTSK and myocardial infarction.