Moreover, under the influence of ATP, the protein levels of Vimentin and E‐Cadherin were almost returned to normal in CYT997‐treated cells as compared to the cells in absence of ATP (Figure 5D), suggesting that CYT997‐induced repression of ATP can reverse EMT phenotype in mesenchymal‐like HNSCC cells, resulting in decreased invasion and metastasis. The gene discussed is VIM; the disease is head and neck squamous cell carcinoma.