The role of TLR7 (inflammatory) and TLR9 (protective) in SLE can be different due to variation in study samples among different studies; nevertheless, TLR9−/− murine models displayed higher TLR7‐mediated inflammation concluding a regulatory role of TLR9.63, 64, 65. This evidence concerns the gene TLR9 and systemic lupus erythematosus.