TLR4 has been reported to promote colon cancer, and its deficiency can alleviate the inflammation as well as tumor burden.69, 70 The liver cancer has also been related to TLR4 activation71; however, its role may be context dependent in skin cancer.72, 73 Similarly, TLRs are also critical for the cellular transformation in breast cancers, as reviewed before,14 can critically modulate the metabolism in the tumor microenvironment,74 and can regulate other signaling networks to favor pro‐ or anti‐tumor outcomes.75, 76, 77. This evidence concerns the gene TLR4 and liver cancer.