LMNA and Alexander disease: While these findings indicate that LMNA gene expression is upregulated in Alexander disease-mutated astrocytes, the fact that the lamin C isoform is expressed at a disproportionately higher level than lamin A suggests that the LMNA mRNA splicing in these GFAP-mutated cells favors lamin C expression over that of lamin A, even more than it already did in normal astrocytes (Jung et al., 2012; Wang et al., 2018).