Thus, although the MEPs are numerically expanded in the bone marrow of Wt1+/R394W mice (Figure 2A), these competitive repopulation data suggest that the Wt1+/R394W MEPs are functionally abnormal, complementary to our finding that Wt1+/R394W mice develop MDS characterized by dyserythropoiesis and anemia. This evidence concerns the gene WT1 and myelodysplastic syndrome.