Wt1+/R394W mice have mild splenomegaly compared to wild type mice (spleen weights, 0.11 ± 0.005 g vs. 0.09 ± 0.007 g for wild type, p = 0.049), but there were no appreciable differences in the peripheral blood counts between 2-month old wild type and Wt1+/R394W littermates (Supplementary Figure 3). The gene discussed is WT1; the disease is Splenomegaly.