NOTCH1 and acute lymphoblastic leukemia: Further, a subset of secondary transplant recipients of Wt1-haploinsufficent bone marrow developed T-ALL after acquiring additional mutations in known leukemic alleles such as Notch1. In comparison, our data supports that the R394W Wt1 mutation behaves in a dominant fashion to induce dyserythropoiesis and myeloid neoplasms.