Thus, although the MEPs are numerically expanded in the bone marrow of Wt1+/R394W mice (Figure 2A), these competitive repopulation data suggest that the Wt1+/R394W MEPs are functionally abnormal, complementary to our finding that Wt1+/R394W mice develop MDS characterized by dyserythropoiesis and anemia. The gene discussed is WT1; the disease is anemia (phenotype).