TET2 and chronic myelomonocytic leukemia: A model of complete conditional Tet2 loss in the hematopoietic compartment demonstrates increased stem cell self-renewal in vitro by serial replating studies and in vivo by competitive transplant studies, occurring to a lesser degree with haploinsufficient Tet2 cells, and mice develop a phenotype resembling chronic myelomonocytic leukemia (CMML) [32].