In a small study of 31 EAC patients with available esophagectomy specimens, Akgun and colleagues [28] reported expression of ERβ in Barrett's metaplasia negative for dysplasia, low-grade dysplasia, high-grade dysplasia and adenocarcinoma and observed a trend of increased expression as esophageal lesions progressed. This evidence concerns the gene ESR2 and adenocarcinoma.