In transgenic AD mouse models, crocetin significantly reduced the pro-inflammatory cytokines and enhanced the anti-inflammatory cytokine in the plasma, suppressed NF-kB activation and p53 expression in the hippocampus, decreased overall insoluble Aβ in the hippocampus, cerebral cortex, and cerebellum, and reversed learning and memory deficits in transgenic AD mice. This evidence concerns the gene TP53 and Alzheimer disease.