NFKB1 and Alzheimer disease: In transgenic AD mouse models, crocetin significantly reduced the pro-inflammatory cytokines and enhanced the anti-inflammatory cytokine in the plasma, suppressed NF-kB activation and p53 expression in the hippocampus, decreased overall insoluble Aβ in the hippocampus, cerebral cortex, and cerebellum, and reversed learning and memory deficits in transgenic AD mice.