APP and Alzheimer disease: As previously reported [17], we observed that the transgenic mice carry a human familial AD gene (amyloid precursor protein with the “Swedish” double mutation, and display age-related Aβ plaque (Fig. 2), quantifiable inflammatory response (Figs. 5 and 6), and memory deficits (Figs. 3 and 4), confirming that the transgenic mice can be valid AD models.