As there has been evidence demonstrating that IFN-γ increases melanoma cell lysis and Ag presentation of new epitopes through upregulation of immunoproteasome proteins (19, 20), it is reasonable to think that, in addition to the primary T cell response against the vaccine Ags, the successive CSF-470 vaccination scheme resulting in an increase of IFN-γ secreting T cells could also promote the presentation of novel, private Ags occurring in tumor microenvironment. The gene discussed is IFNG; the disease is melanoma.