In contrast, ROR2 is overexpressed in several human cancers, including renal cell carcinoma (11, 12), osteosarcoma (10), melanoma (13), stromal tumors (14), as well as breast (15, 16), colorectal (17), oral (18), and pancreatic cancer (19), and has been associated with a more aggressive disease state and poorer patient prognosis within these indications. This evidence concerns the gene ROR2 and hereditary clear cell renal cell carcinoma.