Increased fALFF in bilateral SMC, extending to bilateral paracentral lobule (Figure 1), may be a compensation of hypocretin deficiency in motor cortex among narcolepsy, although a contradictory result has been reported hypo-activity in sensorimotor cortex in narcolepsy by transcranial magnetic stimulation (TMS) in a previous study (32). The gene discussed is HCRT; the disease is narcolepsy.