BIX01294 (adiazepin-quinazolin-amine derivative), the most efficient inhibitor of G9a, transiently reduces methylation of H3K9 and H3K27 in different cancer cells, including glioma cells (Kubicek et al., 2007; Maleszewska et al., 2014; Ciechomska et al., 2016). This evidence concerns the gene EHMT2 and central nervous system cancer.