Conversely, components of the REST complex are targets for down-regulation by certain neurogenic miRNAs, such as miR-9/9∗ and miR-124, suggesting that their neurogenic potential is at least in part due to challenging REST complex levels and/or activity (Visvanathan et al., 2007; Packer et al., 2008), a concept that may have far reaching implications regarding experimental therapeutic strategies for HD. The gene discussed is REST; the disease is Huntington disease.