BDNF and Huntington disease: Acute intraventricular delivery of this small molecule increased the expression of the key neurotrophic factor BDNF, being depleted during disease progression (Zuccato et al., 2001), as well as, several other REST-regulated genes in the prefrontal cortex of mice with QA-induced striatal lesions (Charbord et al., 2013), highlighting its potential therapeutic value in HD.