For example, breast cancer screening considers a mechanism for call and recall of the population, diagnostic tests, false positive findings including subsequent diagnosis and pathology, diagnostic tests including immunohistochemistry for hormone receptor testing, staging for select individuals found to have cancer, health workforce time for treatment, management of treatment related toxicities, inpatient and outpatient costs, surveillance after cancer treatment and monitoring and evaluation of screening. Here, NR4A1 is linked to breast carcinoma.