To date, a consensus on the immuno-phenotype of human HE indicates that this specialized endothelial precursor is contained within a population co-expressing CD31, CD34, VE-cadherin (CD144), and KDR, and lacking the expression of CD43, CD41, and CD45 marking hematopoietic commitment as well as lacking the expression of DLL4, CD73, and CD184, marking further endothelial commitment or arterial specification. Here, CDH5 is linked to hereditary elliptocytosis.