For instance, high concentrations of serum hRNase5/ANG have been observed in patients who suffer from various cancer types, such as colorectal cancer, lung cancer, and acute myelogenous leukemia [44, 55, 193], in which EGFR has been well studied to be a therapeutic target in clinical practice [154, 157, 194]. The gene discussed is EGFR; the disease is lung carcinoma.