As a well-known oncogene that is critical to tumorigenesis, EGFR has been evaluated in clinical trials as the target of effective cancer therapies by mAbs (e.g., cetuximab and panitumumab) or TKIs (e.g., erlotinib, gefitinib, afatinib, and osimertinib) [14–16, 152]. This evidence concerns the gene EGFR and cancer.