The PD‐1/PD‐L1 immune checkpoint has been attracting attention in research on various cancers.18, 19 In addition, recent studies have suggested a link between PD‐L1 expression and EBV infection.12, 17, 25 Our results may be useful for selecting patients in trials in the immune‐oncology era. Here, CD274 is linked to Epstein-Barr virus infection.