Angiotensin-converting enzyme (ACE) inhibitors (e.g., Captopril, Lisinopril, Enalapril, Ramipril) and Angiotensin II receptor blockers (ARB) (e.g., Valsartan, Telmisartan, Losartan) are widely used to treat hypertension, which is a typical hyperfunctional disease. This evidence concerns the gene ACE and hypertensive disorder.