It has also been reported that the NLRP3 Inflammasome inhibits CRC metastatic growth in the liver through enhancing NK cell tumoricidal function that was mediated by IL-18, independent of IFN- γ, as knockout mice for the NLRP3 inflammasome show increased liver CRC metastases [91]. This evidence concerns the gene NLRP3 and colorectal carcinoma.