In the second grade, IL-1R is expressed and in the third progressive stage the NLRP3 inflammasome is active constitutively [137], a correlation has been shown between the NLRP1 and NLRP3 variations and melanoma risk, with the greatest correlation between NLRP1 and nodular melanoma [138]. This evidence concerns the gene NLRP3 and nodular malignant melanoma.