Expression levels of IL1β and NLRP3 were directly correlated with mean diameter of adipocytes (μm) in males, but not in females [157] and it has been suggested that the NLRP3 inflammasome could a novel biomarker for obesity-related metabolic diseases [158, 159], as the high-amplification of IL1β and NLRP3 may be connected to pathophysiological abnormalities in visceral adipose tissue. This evidence concerns the gene NLRP3 and metabolic disease.