NLRP3 and cancer: Pathogens, destructive signals and stresses are the usual stimulatory factors for NLRP3 Inflammasome activation in prostate tissue [126], but other mediators such as uric acid, infections and urine crystals can induce prostate gland (PG) injury that lead to up regulation of proinflammatory cytokines through the activated inflammasome in the PG and lead to cancer progression [127].