Similar results were also observed in chronic myeloid leukemia (CML) patients in which genotyping demonstrated that genetic polymorphisms of IL-1β-rs16944, IL-18-rs1946518, and CARD8-rs2043211 were associated with the pathophysiological characteristics and treatment of CML patients. This evidence concerns the gene IL1B and chronic myelogenous leukemia, BCR-ABL1 positive.