Particularly, the study of Habibi et al. have demonstrated that a 4-week treatment with DAPA attenuated the increase in cardiac mitochondrial fission parallel to the decrease in mitochondrial fusion as evidenced by altered protein expressions such as Mfn-2 and Fis-1 in obese-insulin resistant rats undergoing cardiac ischemia–reperfusion injury [51]. Here, FIS1 is linked to myocardial ischemia.