KMT2A and brain ischemia: Previously, it was reported that suppression on ONOO− formation by either hTrx-1 or an ONOO− scavenger uric acid reduced cerebral infarct size in mice subjected to cerebral ischemia, and peroxynitrite donor Sin-1 markedly attenuated hTrx-1-induced antioxidative/antinitrative effect [19].