KMT2A and brain ischemia: In this study, we have demonstrated that Trx-1 is subject to nitrative modification after brain ischemia/reperfusion insult with following evidence: the nitration content of overall proteins is elevated; the decrement of activity of Trx-1 is correlated with post-translational nitration of Trx-1; sevoflurane preconditioning inhibits nitration of Trx-1 after brain ischemia.