Two additional findings are interesting in this regard: it was previously reported that FSHD myoblasts formed measurably thinner myotubes when subjected to differentiation31; and it was recently reported that the strongest gene expression profile detected in FSHD biopsies was not that of DUX4 up-regulated targets, but rather that of inverse-regulated PAX7 targets24. The gene discussed is PAX7; the disease is facioscapulohumeral muscular dystrophy.