To correlate metabolite profiles in plasma with immune activity, we determined in subsequent plasma samples of the same patients the levels of the infection markers IP-10, sIL-2R, and D-dimer, the inflammation markers IL-6, IL-10, IL-21, IL-18, and MCP-1, and the soluble exhaustion markers sPD1, sPD-L1, sPD-L2, and sTIM3. This evidence concerns the gene IL18 and infection.