DCLK3 and type 2 diabetes mellitus: On the other hand, in the studies by Stocker et al. 11 and Choi et al. 13, the differences in CLR and SrCLR according to MATE2K genotype were smaller than those we reported in our previous study12, but this genotype was significantly associated with the metformin response as determined by the relative change in glycated hemoglobin (HbA1C) in type 2 diabetes patients.