As HTR2B is the most highly expressed HTR in the liver and has been associated with hepatic carbohydrate metabolism21, we generated liver-specific Htr2b KO (Albumin-Cre+/– ; Htr2bflox/flox, Htr2b LKO) mice and induced hepatic steatosis with 8 weeks of HFD feeding to examine the role of hepatic HTR2B in steatotic effects of GDS in the liver. The gene discussed is ALB; the disease is Hepatic steatosis.