Furthermore, HFD-fed Htr2a LKO mice showed decreased hepatic steatosis as examined by histology, NAS, and hepatic TG concentrations (Fig. 4d–f and Supplementary Fig. 2d) without affecting BW, glucose tolerance, insulin sensitivity, and plasma lipid profiles (Supplementary Fig. 2e–h). Here, INS is linked to Hepatic steatosis.