YAP1 and breast carcinoma: As shown in Fig. 3e, the breast cancer cell line MDA-MB-231 and mesothelioma cell line NCI-H2052, cell lines with a known loss of NF2 expression, an upstream negative regulator of YAP, displayed higher phosphorylation of YAP on S127, compared to their counterpart wild-type NF2 cell lines.