Five cancer types - prostate adenocarcinoma (PRAD), chromophobe renal cell carcinoma (KICH), head and neck squamous cell carcinoma (HNSC), oesophageal carcinoma (ESCA), and adenoid cystic carcinoma (ACC) – showed a significant decrease in ZNF185 mRNA level respect to the normal tissues from both TCGA and GTEx database (Fig 4A). The gene discussed is ZNF185; the disease is cancer.