Since there are only few datasets of skin cancer with a very low number of samples, we decided to analyse ZNF185 expression in skin cancer by immunohistochemistry using tissue microarray, containing 42 samples of the cutaneous squamous cell carcinoma (cSCC), 14 samples of the cutaneous basal cell carcinoma (cBCC), 12 samples of cutaneous malignant melanoma (cMM), and 10 samples of the normal skin. This evidence concerns the gene ZNF185 and cutaneous squamous cell carcinoma.