We used paired-end RNA-seq to profile the transcriptomes of primary MoDCs from healthy donors at rest (N = 99), and following stimulation with either recombinant interferon beta (IFNB1), a type 1 interferon that stimulates anti-viral effectors (N = 227), or influenza ΔNS1 (a strain engineered to maximize the type 1 interferon-induced response to infection by the deletion of a key virulence factor; N = 250) (Shapira et al. 2009). This evidence concerns the gene IFNB1 and infection.