In the present study, we used this method to systematically assess the association between GRIA1 rs548294 G>A and rs2195450 C>T polymorphisms and migraine risk, and found that GRIA1 rs548294 G>A polymorphism was not significantly associated with migraine risk, but GRIA1 rs2195450 C>T polymorphism was significantly associated with migraine risk. The gene discussed is GRIA1; the disease is migraine disorder.