The HMGB3 expression in NSCLC and adjacent tissues was measured by RT-qPCR, showing that amongst the 50 cases of NSCLC tissues, the mRNA level of HMGB3 in 34 cases of tissues presented with a higher expression than the adjacent tissues, along with 16 cases of significantly higher (>two-fold increase) than the adjacent tissues (P<0.05) (Figure 2A). This evidence concerns the gene HMGB3 and non-small cell lung carcinoma.