While several other chromosomal translocations have recently been described in salivary gland tumors, such as EWSR1-ATF1 in hyalinizing clear cell carcinoma and PRKD1–3 gene translocations in cribiform adenocarcinomas of the minor salivary glands [39], there remains a paucity of data surrounding the natural history, diagnosis, treatment, and outcomes of this relatively rare disease. This evidence concerns the gene EWSR1 and adenocarcinoma.