Tumor necrosis factor-related apoptosis-inducing ligand [3, 4] (TRAIL, other names: TNFSF10; CD253; Apo-2L; TNLG6A [5]), is a protein belonging to the TNF-superfamily [6] and has been shown in in vitro and in vivo models to induce apoptosis of various types of cancer cells while sparing normal ones [7]. This evidence concerns the gene TNFSF10 and cancer.