In some tumor types, it blocked EMT and tumor progression [46, 47], while in others induced EMT-TFs expression and EMT [45], like we observed in the induction of SNAI1, SNAI2 and ZEB1 expression in MCF7 cells after 5-aza treatment alone or in combination with the SIRT1 inhibitor. Here, SIRT1 is linked to neoplasm.