We focused on the interaction of WISP1 and integrin β5 because: others noted that WISP1 induces IL-6 production through integrin β5 receptor in human synovial fibroblasts [46]; and although several integrins are important in ALI [25], integrin β5 is a central regulator of increased permeability in VILI [26] and CLP [27]. Here, IL6 is linked to acute respiratory distress syndrome.